What to KnowProgramming note: Before the 49ers play the Titans on Sunday at Levi’s Stadium, tune into “49ers Pregame Live” at noon PT on NBC Sports Bay Area or stream the show in the NBC Sports app for a full game preview with Carlos Ramirez, Rod Brooks and Matt Maiocco.The San Francisco 49ers (9-4), fresh off their bye week and clinging to the NFC’s No. 6 playoff seed, welcome the Tennessee Titans (2-11) to Santa Clara for a Week 15 matchup.The banged-up 49ers enter Sunday’s game favored by more than a touchdown for the first time during the 2025 NFL season, opening as 12.5-point favorites over the Titans according to BetMGM Sportsbook.San Francisco kicker Eddy Piñeiro, who has missed the last two games with a hamstring injury, is active for the Week 15 clash and will look to improve upon his perfect 22-for-22 mark on field goals with the 49ers.Defensive lineman Jordan Elliott was a late scratch after sustaining a knee injury before Sunday’s game.Programming note: Immediately after the Week 15 game ends, watch “49ers Postgame Live” on NBC Sports Bay Area or stream the show in the NBC Sports app for full reaction, analysis and interviews.
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