The Buffalo Bills travel to Cleveland this Sunday for a Week 16 matchup where a victory, paired with a loss by either the Colts or Texans, would officially clinch their playoff berth. While the Browns have been eliminated from the postseason, Buffalo remains focused on securing its position and keeping its slim division title hopes alive.

Buffalo’s path to a clinch grew more complicated Wednesday with the surprise absence of two offensive anchors. Tight end Dalton Kincaid (knee) and left tackle Dion Dawkins (illness) were unable to participate in the team’s opening walkthrough. Kincaid leads the team in touchdown catches, while Dawkins’ absence would leave a major void on the blindside against Cleveland’s pass rush.

These concerns join a growing list of sidelined starters including kicker Matt Prater and defensive tackle Jordan Phillips. On a positive note, the Bills saw limited participation from Christian Benford and Terrel Bernard, suggesting a potential defensive boost is on the horizon.

The sudden uncertainty for Kincaid and Dawkins prompted analysts to urgently reevaluate Bills vs. Browns predictions. New simulations focus on Buffalo’s scoring efficiency without its top red-zone threat and the stability of the line.

The results of these simulations were compared to updated sportsbook odds to compile the data-driven Bills-Browns preview below.

Bills vs. Browns betting preview

Utilize the interactive widget below to view the current spread, over/under, and moneyline betting odds and probabilities for the Bills-Browns game at Huntington Bank Field.

This prediction and best bet for Sunday’s NFL matchup between the Bills and Browns is from Dimers.com, a leader in sports betting predictions.

Check out all the important details on today’s game, as well as the best odds sourced from the top sportsbooks in the country.

Game details

Key information on the Bills vs. Browns matchup, including where the game is and what time it kicks off.

Teams: Buffalo Bills vs. Cleveland BrownsDate: Sunday, December 21, 2025Kickoff: 1 p.m. ESTLocation: Huntington Bank FieldNFL standings: Current NFL division standingsNFL injuries: Check the latest updates to the official NFL injury reportOdds

The latest and best odds for the NFL clash between the Bills and Browns.

Spread: Bills -10.5 (-105), Browns +10.5 (-115)Moneyline: Bills -625, Browns +490Total: Over/Under 41.5 (-108/-110)

The odds and lines featured here are the best available from selected sports betting sites at the time of publication and are subject to change.

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Expert prediction: Bills vs. Browns

Using advanced data analysis and advanced algorithms, the experts at Dimers have performed 10,000 simulations of Sunday’s Bills vs. Browns game.

According to Dimers’ independent predictive analytics model, the Bills are more likely to defeat the Browns at Huntington Bank Field. This prediction is based on the model giving the Bills an 85% chance of winning the game.

Elsewhere on the betting board, Dimers predicts that the bookmakers have gotten it right and the Bills and Browns each have a 50% chance of covering the spread, while the 41.5-point over/under is also considered an equal 50-50 chance of hitting.

As always, these predictions and probabilities are accurate at the time of publication but are subject to potential changes.

Bills vs. Browns best bet

Our top pick for the Bills vs. Browns Week 16 NFL matchup is to bet on the Bills moneyline (-625).

This expert betting advice is based on detailed modeling and valuable wagering intelligence, designed to deliver you the best possible plays.

Score prediction for Bills vs. Browns

Dimers’ predicted final score for the Buffalo vs. Cleveland game on Sunday has the Bills winning 25-15.

This expert prediction is based on each team’s average score following 10,000 game simulations, offering a glimpse into the potential outcome.

NFL player props: Sunday

NFL player props are a common way to wager on Sunday’s game without necessarily betting on its outcome.

This article features the most likely first and anytime touchdown scorers for the Bills and Browns, as well as projected player stats.

Buffalo BillsFirst touchdown scorer predictionsJames Cook: 13.4% probabilityJosh Allen: 11.6% probabilityKhalil Shakir: 5.2% probabilityAnytime touchdown predictionsJames Cook: 54.2% probabilityJosh Allen: 48.9% probabilityKhalil Shakir: 26.1% probabilityProjected box score leadersQB passing yards: Josh Allen, 214 yardsReceiving yards: Khalil Shakir, 47 yardsRushing yards: James Cook, 92 yardsCleveland BrownsFirst touchdown scorer predictionsQuinshon Judkins: 10.7% probabilityHarold Fannin: 5.0% probabilityJerry Jeudy: 3.5% probabilityAnytime touchdown predictionsQuinshon Judkins: 46.3% probabilityHarold Fannin: 25.2% probabilityJerry Jeudy: 18.2% probabilityProjected box score leadersQB passing yards: Shedeur Sanders, 182 yardsReceiving yards: Harold Fannin, 51 yardsRushing yards: Quinshon Judkins, 59 yardsNFL Week 16: Bills vs. Browns

Get ready for Sunday’s matchup between the Bills and Browns in Week 16 of the NFL season at Huntington Bank Field, which is scheduled to start at 1 p.m. EST. We emphasize that all of the NFL best bets and NFL predictions in this article are derived from 10,000 data-driven simulations of the Bills vs. Browns matchup, and they are correct at the time of publication to help you make better decisions when placing bets at online sportsbooks.

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