The Denver Broncos (12-2) take an 11-game winning streak into a matchup with the Jacksonville Jaguars (10-4), winners of five in a row, on Sunday, December 21, 2025 at Empower Field at Mile High. Denver is a 3.5-point favorite in the contest.

Broncos vs. Jaguars game infoGame day: Sunday, December 21, 2025Game time: 4:05 p.m. ETTV channel: FOXLocation: Denver, ColoradoStadium: Empower Field at Mile HighLive stream: Watch this game on Fubo (Regional restrictions may apply)

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Broncos vs. Jaguars odds & betting linesSpread favorite: Denver (-3.5)Moneyline: Denver (-185), Jacksonville (+154)Total: 47 points

NFL odds courtesy of BetMGM Sportsbook. Odds updated Friday at 10:55 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.

Broncos vs. Jaguars recent matchupsDenver holds the edge versus Jacksonville over the last three matchups between the two squads, recording a 2-1 record.Denver outscored Jacksonville 68-56 in those three head-to-head matchups.Broncos vs. Jaguars betting insightsDenver is 6-8-0 against the spread through 14 opportunities so far this season. The Broncos have won eight of the nine games they have played as the moneyline favorite this season. Jacksonville has nine wins against the spread in 14 opportunities so far this season (9-5-0). This is the ninth game this year the Jaguars are the moneyline underdog. They are 4-4 in games as an underdog.Broncos scoring insightsThe Broncos put up 27.3 points per game at home, better than their 21.6 average on the road.On defense, Denver concedes fewer points at home (17.6 per game) than away (19.7).The Broncos have put up 19 points per game in the division, below their average in non-division games of 26.6.Denver is allowing 16.5 points per game in divisional matchups, which is better than its 19.5 average outside the division.Looking at the Broncos’ last three games, they have generated 28.3 points per game on offense (eighth-ranked) and have surrendered 23 points per game on defense (15th-ranked).Jaguars scoring insightsAt home, the Jaguars put up 26.5 points per game, slightly worse than their 27.3 average on the road.On defense, Jacksonville concedes fewer points at home (18.5 per game) than away (24).Offensively, the Jaguars are scoring 26.8 points per game in divisional contests, which is slightly less than their 26.9 average versus the rest of the league.Jacksonville is conceding 17 points per game in divisional contests, which is better than its 22.4 average in non-division games.In their past three games, the Jaguars are putting up 36.3 points per game (second-best in league), and allowing 14 (second-best).Broncos injury reportBroncos:
Karene Reid: questionable (Hamstring),
Marvin Mims: Full Participation in Practice (Biceps),
Mike McGlinchey: Full Participation in Practice (Neck),
RJ Harvey: Full Participation in Practice (Ribs),
Pat Bryant: Full Participation in Practice (Hamstring),
Justin Strnad: out (Foot),
Ben Powers: questionable (Biceps),
Luke Wattenberg: Full Participation in Practice (Ankle),
John Franklin-Myers: Full Participation in Practice (NIR – Rest)Jaguars injury reportJaguars:
Jalen McLeod: out (Ankle),
Arik Armstead: Full Participation in Practice (Hand),
Travon Walker: Full Participation in Practice (Knee),
Walker Little: Full Participation in Practice (Concussion),
Josh Hines-Allen: Full Participation in Practice (Illness),
Ezra Cleveland: Limited Participation in Practice (Shoulder),
Danny Striggow: out (Ankle),
Bhayshul Tuten: out (Finger)

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