Check out the injury report for the San Francisco 49ers (10-4), which currently includes 12 players listed (including Christian McCaffrey), as the 49ers ready for their matchup against the Indianapolis Colts (8-6) at Lucas Oil Stadium, on Monday, Dec. 22 at 8:15 p.m. ET.
Watch San Francisco 49ers vs. Indianapolis Colts on Fubo! (Regional restrictions may apply)
49ers vs Colts TV channel & game infoGame day: Monday, December 22, 2025Game time: 8:15 p.m. ETLocation: Indianapolis, IndianaStadium: Lucas Oil StadiumTV channel: ESPNLive stream: Watch on Fubo! (Regional restrictions may apply)
Watch San Francisco 49ers vs. Indianapolis Colts on Fubo! (Regional restrictions may apply)
49ers injury reportKurtis Rourke | QB (Out)Injury: KneePractice Status: Full Participation in PracticeRicky Pearsall | WR (Out)Injury: KneePractice Status: Did Not Participate In Practice2025 Receiving Stats: 45 Targets | 31 Receptions | 443 Yards | 0 TouchdownsRenardo Green | CB (Out)Injury: NeckPractice Status: Limited Participation in Practice2025 Defensive Stats: 0.0 Sacks | 0.0 Tackles for Loss | 52 Tackles | 0 Interceptions | 9 Passes DefendedYetur Gross-Matos | DL (Questionable)Injury: HamstringPractice Status: Did Not Participate In PracticeSam Okuayinonu | DLInjury: AnklePractice Status: Full Participation in Practice2025 Defensive Stats: 2.0 Sacks | 3.0 Tackles for Loss | 31 Tackles | 0 Interceptions | 0 Passes DefendedChristian McCaffrey | RBInjury: NIR – RestPractice Status: Full Participation in Practice2025 Rushing: 259 Attempts | 922 Yards | 9 Touchdowns2025 Receiving Stats: 108 Targets | 86 Receptions | 820 Yards | 5 TouchdownsJordan Elliott | DLInjury: KneePractice Status: Full Participation in Practice2025 Defensive Stats: 0.0 Sacks | 1.0 Tackles for Loss | 29 Tackles | 0 Interceptions | 0 Passes DefendedSpencer Burford | OLInjury: KneePractice Status: Full Participation in Practice2025 Season Stats: 2 Games PlayedTatum Bethune | LBInjury: AnklePractice Status: Full Participation in Practice2025 Defensive Stats: 0.0 Sacks | 2.0 Tackles for Loss | 64 Tackles | 0 Interceptions | 1 Pass DefendedDee Winters | LBInjury: WristPractice Status: Full Participation in Practice2025 Defensive Stats: 0.0 Sacks | 7.0 Tackles for Loss | 89 Tackles | 0 Interceptions | 3 Passes DefendedTrent Williams | OTInjury: NIR – RestPractice Status: Full Participation in Practice2025 Season Stats: 5 Games PlayedNickolas Martin | LBInjury: ConcussionPractice Status: Did Not Participate In Practice49ers insightsThe 49ers have scored more points per game over their previous three matchups (27.7) than they have averaged for the season (24.6).Turning our attention to yardage, San Francisco’s offense has seen a small decrease in production over its last three games, collecting 340.7 total yards per game, compared to its season-long average of 347.5 yards per contest.In the passing game, the 49ers have seen a downtick in production over their last three games, collecting 215.3 passing yards per game, compared to their season-long average of 246.1 passing yards per contest.San Francisco has seen an increase in production on the ground over its last three matchups, running for 125.3 yards per contest, compared to its season-long average of 101.4 rushing yards per game.49ers vs Colts odds
NFL odds courtesy of BetMGM. Odds updated Monday at 1:29 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread Favorite: 49ers (-5.5)Moneyline: 49ers (-260), Colts (+210)Total: 46 points
Watch San Francisco 49ers vs. Indianapolis Colts on Fubo! (Regional restrictions may apply)