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The NFL Week 16 schedule concludes with the San Francisco 49ers vs Indianapolis Colts on Monday Night Football at the Colts’ Lucas Oil Stadium on Dec. 22.
Here’s what you need to know before the NFL Week 16 Monday Night Football matchup, including time, TV channels, streaming information and NFL Week 16 announcers for the game.
The 49ers are coming off a 37-24 win against the Tennessee Titans in their NFL Week 15 game.
The Colts lost to the Seattle Seahawks, 18-16.
San Francisco enters the game with a 10-4 record. Indianapolis is 8-6 on the season.
NFL Week 17 picks: Cowboys at Commanders | Lions at Vikings | Broncos at Chiefs | Texans at Chargers | Ravens at Packers | Seahawks at Panthers | Cardinals at Bengals | Steelers at Browns | Jaguars at Colts | Buccaneers at Dolphins | Patriots at Jets | Saints at Titans | Giants at Raiders | Eagles at Bills | Bears at 49ers | Rams at Falcons | The Republic’s score predictions
Watch 49ers at Colts on FUBO (free trial)
What time is Monday Night Football?
The 49ers vs Colts NFL Week 16 Monday Night Football game is scheduled to begin at 6:15 p.m. MST, 8:15 p.m. ET.
What channel is Monday Night Football on?
The Monday Night Football NFL Week 16 game between the 49ers and Colts will be shown nationally on ESPN.
How can I stream Monday Night Football?
The NFL Week 16 49ers at Colts Monday Night Football game can be streamed on FUBO, which offers a free trial, as well as other streaming services that carry ESPN.
Who are the announcers for Monday Night Football?
Joe Buck will have the play-by-play call for the 49ers-Colts game in NFL Week 16 on Monday Night Football, with Troy Aikman as the analyst.
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Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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