The conclusion of a chaotic Week 16 slate arrives on “Monday Night Football” between two franchises with varying playoff outlooks: the Indianapolis Colts (8-6) host the San Francisco 49ers (10-4).

The Colts’ playoff chances have taken a nosedive along with their record of late: they’re on a four-game losing streak after an 8-2 start, which has dropped their playoff chances from 98% to just 4.1%, according to SportsLine. The last team to miss the postseason after an 8-2 or better start was the 1995 Raiders. 

Indianapolis likely needs to win all three of its remaining games against the 49ers, Jaguars (11-4) and Texans (10-5) in order to crack the AFC’s postseason picture. The Colts possess the NFL’s most intriguing quarterback situation with 44-year-old eight-time Pro Bowler Philip Rivers behind center following Daniel Jones’ season-ending Achilles injury. 

San Francisco has already clinched an NFC playoff spot, but much bigger goals remain available. If the 49ers win their three remaining games against the Colts, Bears (11-4) and Seahawks (12-3), the 49ers would win the NFC West and secure the conference’s top seed. That would certainly simplify their path to playing in Super Bowl LX on their home turf at Levi’s Stadium.

Can the 49ers secure the first of three consecutive victories required to rise to the top of the NFC? Or will the Colts preserve their playoff aspirations for another week? Stay tuned to the live blog below for updates, analysis, highlights and more. 

Where to watch 49ers vs. ColtsDate: Monday, Dec. 22 | Time: 8:15 p.m. ETLocation: Lucas Oil Stadium (Indianapolis)TV: ESPN | Stream: Fubo (try for free)Follow: CBS Sports AppOdds: 49ers -5.5, O/U 45.5 (via DraftKings Sportsbook)