Christian McCaffrey and the San Francisco 49ers delivered a statement performance on Monday Night Football, rolling past the Indianapolis Colts 48-27 in a dominant Week 16 road victory.
From start to finish, San Francisco controlled the tempo, lighting up the scoreboard in every quarter and leaving the Colts’ defense searching for answers.
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At the heart of the offensive explosion was McCaffrey, whose versatility and consistency once again defined the night.
San Francisco wasted no time establishing its game plan.
The offense was efficient, physical, and relentless, piling up points in bunches while keeping Indianapolis off balance.
McCaffrey served as the engine, punishing the Colts between the tackles and slipping into open space as a receiver.
He finished the evening with 21 rushing attempts for 117 yards, while adding six catches for 29 yards and two touchdowns, showcasing the full range of his skill set.
The matchup also carried added intrigue as it featured two of the NFL’s top running backs in McCaffrey and Colts star Jonathan Taylor.
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While Taylor found the end zone once, his production was limited to 46 yards on 16 carries.
McCaffrey, meanwhile, thrived against the tougher defensive front, more than doubling Taylor’s total yardage from scrimmage and outscoring him in a convincing team win.
The contrast highlighted McCaffrey’s unique ability to influence the game in multiple ways.
Beyond the immediate impact, the night marked a significant milestone in McCaffrey’s season.
With his performance, he eclipsed 1,000 rushing yards for the first time since his remarkable 2023 campaign.
Entering Week 16, he needed just 78 yards to reach the mark and cleared it comfortably, reaffirming his place among the league’s elite backs.
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He now sits only 151 receiving yards away from joining the exclusive 1,000-yard rushing and receiving club with two games still left to play.
Now in his ninth NFL season and fourth with San Francisco, McCaffrey’s path hasn’t always been smooth.
Injuries limited him throughout the 2024 season, casting uncertainty on his availability and impact.
In 2025, however, he has returned to top form, compiling 259 carries for 922 yards and nine touchdowns before Monday night, along with 86 receptions for 820 yards and five scores.
Against Indianapolis, McCaffrey made it clear he is peaking at the right time.
His blend of vision, toughness, and explosiveness fueled a complete team effort and reinforced why the 49ers remain one of the most dangerous teams in football as the postseason approaches.