The Jacksonville Jaguars (11-4) visit the Indianapolis Colts (8-7) at Lucas Oil Stadium in Indianapolis for a Week 17 showdown, and USA TODAY’s panel of NFL experts have locked in their picks and predictions for the action. Here’s everything you need to know before kickoff on Sunday, December 28, including live updated odds and injury report news.

NameWeek 162025 SeasonBlake Schuster12-3-1127-94-6Jon Hoefling8-7-1117-117-6Tyler Dragon6-9-1116-118-6Chris Bumbaca8-7-1101-104-5Lorenzo ReyesN/A107-112-5Jordan Mendoza11-4-198-107-5Richard Morin10-5-147-34-3Colts vs. Jaguars live odds, moneyline, over/under

Opening Lines

Spread: Colts (-1.5)Moneyline: Colts (-125), Jaguars (+105)Over/Under: 45.5

Get the edge with our exclusive NFL betting picks

Colts vs. Jaguars picks against the spreadJordan Mendoza: Jacksonville Jaguars (-6.5)

Can anyone stop Trevor Lawrence? With the way Indianapolis is playing right now, probably not. The Jaguars stay in the hunt for a top seed by sending the Colts spiral down further.

Tyler Dragon: Jacksonville Jaguars (-6.5)

Philip Rivers is strengthening his case for the Hall of Fame. But the Jaguars are rolling right now.

Blake Schuster: Jacksonville Jaguars (-6.5)

The Philip Rivers Experience is fun while it lasts, but I just watched the Jags eviscerate the Broncos in Denver. I can’t fade Jacksonville in a dome now.

Jon Hoefling: Indianapolis Colts (+6.5)

Rivers has played better than expected and the Jags are coming off an emotional win over Denver. Prime candidate for a shocking defeat.

Lorenzo Reyes: Jacksonville Jaguars (-6.5)

The Jaguars are excellent at stopping the rush, which is where the Colts are strongest, behind Jonathan Taylor. Indy basically has nothing to play for, and Philip Rivers may struggle to sustain the offense. Trevor Lawrence is playing extremely well, so I love the Jaguars here, as long as it stays below a touchdown.

Christopher Bumbaca: Jacksonville Jaguars (-6.5)

Everybody wants in on the Phil Rivers revival tour. I’ll pass and stick with the team playing sublime football.

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