The San Francisco 49ers (11-4) have nine players on the injury report, including Christian McCaffrey, ahead of their matchup against the Chicago Bears (11-4) at Levi’s Stadium, on Sunday, Dec. 28 at 8:20 p.m. ET.
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49ers vs Bears TV channel & game infoGame day: Sunday, December 28, 2025Game time: 8:20 p.m. ETLocation: Santa Clara, CaliforniaStadium: Levi’s StadiumTV channel: NBC/PeacockLive stream: Watch on Fubo! (Regional restrictions may apply)
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49ers injury reportRenardo Green | CB (Out)Injury: NeckPractice Status: Limited Participation in Practice2025 Defensive Stats: 0.0 Sacks | 0.0 Tackles for Loss | 52 Tackles | 0 Interceptions | 9 Passes DefendedKurtis Rourke | QB (Out)Injury: KneePractice Status: Full Participation in PracticeRicky Pearsall | WR (Questionable)Injury: KneePractice Status: Limited Participation in Practice2025 Receiving Stats: 45 Targets | 31 Receptions | 443 Yards | 0 TouchdownsGeorge Kittle | TE (Questionable)Injury: AnklePractice Status: Did Not Participate In Practice2025 Receiving Stats: 62 Targets | 52 Receptions | 599 Yards | 7 TouchdownsSam Okuayinonu | DLInjury: AnklePractice Status: Full Participation in Practice2025 Defensive Stats: 2.0 Sacks | 3.0 Tackles for Loss | 34 Tackles | 0 Interceptions | 0 Passes DefendedChristian McCaffrey | RBInjury: RestPractice Status: Full Participation in Practice2025 Rushing: 280 Attempts | 1,039 Yards | 9 Touchdowns2025 Receiving Stats: 116 Targets | 92 Receptions | 849 Yards | 7 TouchdownsYetur Gross-Matos | DLInjury: KneePractice Status: Limited Participation in PracticeTatum Bethune | LBInjury: AnklePractice Status: Full Participation in Practice2025 Defensive Stats: 0.0 Sacks | 2.0 Tackles for Loss | 73 Tackles | 0 Interceptions | 2 Passes DefendedTrent Williams | OTInjury: RestPractice Status: Full Participation in Practice2025 Season Stats: 5 Games Played49ers insightsThe 49ers have compiled more points per game over their last three matchups (37.0) than they have averaged for the season (26.1).Turning our attention to yardage, San Francisco has racked up more total yards per game over its previous three matchups (374.0) than it has averaged for the season (353.7).In the passing game, the 49ers are piling up 249.4 passing yards per game this season, but they’ve been slightly less effective over their last three games, averaging 249.3 passing yards per contest.San Francisco has seen an increase in production on the ground over its last three matchups, rushing for 124.7 yards per contest, compared to its season-long average of 104.3 rushing yards per game.49ers vs Bears odds
NFL odds courtesy of BetMGM. Odds updated Saturday at 9:29 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread Favorite: 49ers (-3)Moneyline: 49ers (-181), Bears (+151)Total: 52.5 points
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