The Buffalo Bills (11-4) host the Philadelphia Eagles (10-5) on Sunday at 4:25 p.m. ET, in a matchup featuring a pair of the top offensive performers in the league in James Cook and Jalen Hurts.
The Bills rank 11th in total defense this season (311.4 yards allowed per game), but they’ve been playing really well on the offensive side of the ball, ranking third-best in the NFL with 373.1 total yards per game. In terms of total offense, the Eagles rank 22nd in the NFL (319.6 total yards per game) and 12th on the other side of the ball (315.7 total yards allowed per contest).
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Bills vs Eagles: live streaming info, TV channel & game timeGame day: Sunday, December 28, 2025Game time: 4:25 p.m. ETLocation: Orchard Park, New YorkStadium: Highmark StadiumTV channel: FOXLive stream: Watch on Fubo! (Regional restrictions may apply)
Watch Buffalo Bills vs. Philadelphia Eagles on Fubo! (Regional restrictions may apply)
Bills vs Eagles betting lines
NFL odds courtesy of BetMGM. Odds updated Sunday at 12:22 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread Favorite: Bills (-1.5)Moneyline: Bills (-124), Eagles (+104)Total: 44 points
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