Updated Jan. 10, 2026, 7:52 p.m. ET

The Wild Card round of the NFL playoffs has 3 games on Sunday, the first of which has the No. 6 seed Buffalo Bills (12-5) at the No. 3 seed Jacksonville Jaguars (13-4). Kickoff from EverBank Stadium in Jacksonville, Florida, is at 1 p.m. ET (CBS). Let’s analyze BetMGM Sportsbook’s NFL odds around the Bills vs. Jaguars odds and make our expert NFL picks and predictions for the best bets.

The Bills enter the postseason having won 5 of their last 6 games. They are in the playoffs for the seventh straight year. They ended the season with a 35-8 home victory over the New York Jets as 13.5-point favorites with the Over (39.5) cashing.

The Jaguars won the AFC South by winning their final 8 games of the regular season. They ended the year with a 41-7 home win over the Tennessee Titans as 13.5-point favorites with the Over (46.5) cashing.

The all-time series between the Bills and Jaguars is tied 10-10, and the Jags are 2-0 against the Bills in the playoffs, winning AFC Wild Card games in 1996 and 2018. They last played in 2024, a 47-10 Bills win in Orchard Park as 4.5-point favorites with the Over (46.5) cashing.

Watch the NFL on Fubo!Bills at Jaguars odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 7:01 p.m. ET.

Moneyline (ML): Bills -105 (bet $105 to win $100) | Jaguars -115 (bet $115 to win $100)Against the spread (ATS): Bills +1 (-110) | Jaguars -1 (-110)Over/Under (O/U): 51.5 (O: -115 | U: -105)Bills at Jaguars key injuries

Bills

LB Terrel Bernard (calf) outCB Maxwell Hairston (ankle) outS Damar Hamlin (pectoral) outRB Ty Johnson (ankle) questionableWR Josh Palmer (ankle) questionableK Matt Prater (quad) questionableLB Shaq Thompson (neck) questionable

Jaguars

OL Cole Van Lanen (knee) questionableBills at Jaguars picks and predictionsPrediction

Bills 30, Jaguars 28

The Bills have perhaps the most pressure in the postseason, as they have been eliminated by the Kansas City Chiefs in 4 of the last 5 years. The Chiefs did not make the postseason, so they and QB Josh Allen are the team everyone looks to.

However, the Jags are red-hot with 8 consecutive wins, averaging 33.6 points per game (PPG) in that stretch. Opponents have scored 20 or fewer points in 7 of those 8 games.

The Bills have the No. 1 rushing attack in the league while the Jags have the No. 1 run defense in the league.

Allen had 25 TD passes and 14 rushing TD while Jaguars QB Trevor Lawrence threw 29 TD passes and rushed for 9.

This has the promise to be one of the most exciting games of the weekend, but the Bills’ playoff experience gets the edge.

BET BILLS (-105).

The Bills ML is slightly better value than the spread, but consider an alternate spread. Buffalo had one 1-point win this season, the 41-40 season-opening win over the Baltimore Ravens.

If you want just a little better return, consider BILLS -1.5 ALTERNATE SPREAD (+105).

The Bills averaged 28.3 PPG in the regular season and scored 35 or more in 3 of their final 5 games.

The Jags averaged 33.6 PPG in their 8-game winning streak.

Both Lawrence and Allen are big touchdown producers. Expect a shootout in Florida Sunday.

BET OVER 51.5 (-115).

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