The Buffalo Bills will travel to Empower Field at Mile High to face the Denver Broncos in the AFC Divisional Round on Saturday. Kickoff is scheduled for 4:30 p.m. EST on CBS.

Uncertainty surrounding Buffalo’s depleted receiving corps has become a major storyline heading into this high-stakes matchup. Third-year WR Tyrell Shavers, who finished second on the team in yards per reception, remains out after tearing his ACL during the Bills’ Wild Card victory. Head coach Sean McDermott confirmed the news Tuesday, leaving Buffalo with just three healthy receivers on the active roster.

Rookie Keon Coleman and veteran Khalil Shakir are expected to shoulder the load if reinforcements aren’t elevated. The Bills are also monitoring QB Josh Allen, whose head, hand, and leg injuries were exacerbated in Jacksonville.

Denver’s defense is also seeing changes. Linebacker Dre Greenlaw, who has been sidelined with a hamstring injury since Week 16, returned to practice Tuesday. Head coach Sean Payton expressed optimism, noting, “It’s good to have a healthy Dre Greenlaw back.”

This update prompted analysts to reevaluate their Bills vs. Broncos predictions and player stat projections using new simulations that factored in Buffalo’s extensive injury list. The results were compared to updated sportsbook odds to compile the data-driven preview below.

Bills vs. Broncos betting preview

Explore the interactive widget below to see the current spread, over/under, and moneyline betting odds and probabilities for the Bills-Broncos game at Empower Field at Mile High.

This prediction and best bet for Saturday’s NFL matchup between the Bills and Broncos is from Dimers.com, a leader in sports betting predictions.

Check out all the important details on today’s game, as well as the best odds sourced from the top sportsbooks in the country.

Game details

The key information you need before the Bills vs. Broncos NFL game.

Teams: Buffalo Bills vs. Denver BroncosDate: Saturday, January 17, 2026Kickoff: 4:30 p.m. ESTLocation: Empower Field at Mile HighNFL standings: Current NFL division standingsNFL injuries: Check the latest updates to the official NFL injury reportOdds

Odds for the key markets in the Bills-Broncos NFL battle.

Spread: Bills +1 (-115), Broncos -1 (-105)Moneyline: Bills -108, Broncos -108Total: Over/Under 46.5 (-108/-110)

The odds and lines presented in this article are the best available from selected sports betting sites at the time of publication and are subject to change.

Expert prediction: Bills vs. Broncos

Using trusted data analysis and computer power, the experts at Dimers have performed 10,000 simulations of Saturday’s Bills vs. Broncos game.

According to Dimers’ independent predictive analytics model, the Broncos are more likely to defeat the Bills at Empower Field at Mile High. This prediction is based on the model giving the Broncos a 56% chance of winning the game.

Furthermore, Dimers predicts that the Broncos (-1) have a 52% chance of covering the spread, while the over/under total of 46.5 points is considered an equal 50-50 chance of hitting.

As always, these predictions and probabilities are correct at the time of publication but are subject to change.

Bills vs. Broncos best bet

Our top pick for the Bills vs. Broncos game on Saturday is to bet on the Broncos moneyline (-108).

This expert betting advice is formulated through comprehensive modeling and valuable wagering intelligence, designed to help you make smarter investments.

Score prediction for Bills vs. Broncos

Dimers’ predicted final score for the Buffalo vs. Denver game on Saturday has the Broncos winning 23-22.

This expert prediction is based on each team’s average score following 10,000 game simulations, offering a glimpse into the potential outcome.

NFL player props: Saturday

NFL player prop picks are an exciting way to wager on Saturday’s game without necessarily betting on its outcome.

This article features the most likely first and anytime touchdown scorers for the Bills and Broncos, as well as projected player stats.

Buffalo BillsFirst touchdown scorer predictionsJames Cook: 12.2% probabilityJosh Allen: 9.9% probabilityKhalil Shakir: 4.7% probabilityAnytime touchdown predictionsJames Cook: 57.3% probabilityJosh Allen: 49.9% probabilityKhalil Shakir: 28.0% probabilityProjected box score leadersQB passing yards: Josh Allen, 216 yardsReceiving yards: Khalil Shakir, 54 yardsRushing yards: James Cook, 84 yardsDenver BroncosFirst touchdown scorer predictionsRJ Harvey: 11.8% probabilityCourtland Sutton: 6.6% probabilityJaleel McLaughlin: 4.1% probabilityAnytime touchdown predictionsRJ Harvey: 53.4% probabilityCourtland Sutton: 34.8% probabilityJaleel McLaughlin: 23.3% probabilityProjected box score leadersQB passing yards: Bo Nix, 219 yardsReceiving yards: Courtland Sutton, 54 yardsRushing yards: RJ Harvey, 52 yardsNFL Week 20: Bills vs. Broncos

Get ready for Saturday’s game between the Bills and Broncos in the Divisional Round of the NFL season at Empower Field at Mile High, which is scheduled to start at 4:30 p.m. EST. We emphasize that all of the NFL predictions and NFL best bets on this page are derived from 10,000 data-driven simulations of the Bills vs. Broncos matchup, and they are correct at the time of publication. They are intended to assist you make better decisions when placing bets at online sportsbooks.

Please note that when engaging in online betting, it is important to exercise responsible gambling practices and seek reliable sources for the latest and most accurate information.

If you or a loved one has questions or needs to talk to a professional about gambling, call 1-800-GAMBLER or visit 1800gambler.net for more information.

If you purchase a product or register for an account through a link on our site, we may receive compensation. By using this site, you consent to our User Agreement and agree that your clicks, interactions, and personal information may be collected, recorded, and/or stored by us and social media and other third-party partners in accordance with our Privacy Policy.