Arizona Cardinals head coach Jonathan Gannon after first day of OTAs
Arizona Cardinals head coach Jonathan Gannon speaks to the media on the first day of organized team practice in Tempe on May 28, 2025.
How many games will the Arizona Cardinals win in the 2025 NFL regular season?
ESPN Analytics has revealed its Matchup Predictor numbers for the 17 games in the upcoming season, and they offer some interesting win probabilities, potentially seeing a difficult season ahead for Arizona.
Take a look at the site’s picks for the Cardinals’ game each week, beginning with the season-opening NFL Week 1 game at the New Orleans Saints and ending with the NFL Week 18 game at the Los Angeles Rams.
How correct will the analytics end up being?
The site allows for the possibility of ties, so the numbers add up to just less than 100%. All times MST. Arizona’s bye week is in Week 8.
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Cardinals NFL Week 1 prediction: Sept. 7 at New Orleans Saints, CBS, 10 a.m.
Cardinals have a 57.1% chance to beat the Saints in NFL Week 1.
The site gives the Saints a 42.6% shot at winning the NFL Week 1 game, with the remaining percentage accounting for a tie.
Cardinals predicted record: 1-0
Cardinals NFL Week 2 prediction: Sunday, Sept. 14 vs. Carolina Panthers, CBS, 1:05 p.m.
Cardinals have a 60% chance to beat the Panthers in NFL Week 2.
The site gives the Panthers a 39.7% shot at winning the NFL Week 2 game, with the remaining percentage accounting for a tie.
Cardinals predicted record: 2-0
Cardinals NFL Week 3 prediction: Sunday, Sept. 21 at San Francisco 49ers, Fox, 1:25 p.m.
Cardinals have a 39.8% chance to beat the 49ers in NFL Week 3.
The site gives the 49ers a 59.8% shot at winning the NFL Week 3 game, with the remaining percentage accounting for a tie.
Cardinals predicted record: 2-1
Cardinals NFL Week 4 prediction: Thursday, Sept. 25 vs. Seattle Seahawks, Prime Video, 5:15 p.m.
Cardinals have a 54.4% chance to beat the Seahawks in NFL Week 4.
The site gives the Seahawks a 45.2% shot at winning the NFL Week 4 game, with the remaining percentage accounting for a tie.
Cardinals predicted record: 3-1
Cardinals NFL Week 5 prediction: Sunday, Oct. 5 vs. Tennessee Titans, CBS, 1:05 p.m.
Cardinals have a 63.9% chance to beat the Titans in NFL Week 5.
The site gives the Titans a 35.8% shot at winning the NFL Week 5 game, with the remaining percentage accounting for a tie.
Cardinals predicted record: 4-1
Cardinals NFL Week 6 prediction: Sunday, Oct. 12 at Indianapolis Colts, Fox, 10 a.m.
Cardinals have a 49.3% chance to beat the Colts in NFL Week 6.
The site gives the Colts a 50.3% shot at winning the NFL Week 6 game, with the remaining percentage accounting for a tie.
Cardinals predicted record: 4-2
Cardinals NFL Week 7 prediction: Sunday, Oct. 19 vs. Green Bay Packers, Fox, 1:25 p.m.
Cardinals have a 44.7% chance to beat the Packers in NFL Week 7.
The site gives the Packers a 55% shot at winning the NFL Week 7 game, with the remaining percentage accounting for a tie.
Cardinals predicted record: 4-3
Cardinals NFL Week 9 prediction: Monday, Nov. 3 at Dallas Cowboys, ESPN/ABC, 6:15 p.m.
Cardinals have a 46.1% chance to beat the Cowboys in NFL Week 9.
The site gives the Cowboys a 53.5% shot at winning the NFL Week 9 game, with the remaining percentage accounting for a tie.
Cardinals predicted record: 4-4
Cardinals NFL Week 10 prediction: Sunday, Nov. 9 at Seattle Seahawks, CBS, 2:05 p.m.
Cardinals have a 47.4% chance to beat the Seahawks in NFL Week 10.
The site gives the Seahawks a 52.2% shot at winning the NFL Week 10 game, with the remaining percentage accounting for a tie.
Cardinals predicted record: 4-5
Cardinals NFL Week 11 prediction: Sunday, Nov. 16 vs. San Francisco 49ers, Fox, 2:05 p.m.
Cardinals have a 48.6% chance to beat the 49ers in NFL Week 11.
The site gives the 49ers a 51% shot at winning the NFL Week 11 game, with the remaining percentage accounting for a tie.
Cardinals predicted record: 4-6
Cardinals NFL Week 12 prediction: Sunday, Nov. 23 vs. Jacksonville Jaguars, CBS, 2:05 p.m.
Cardinals have a 55.3% chance to beat the Jaguars in NFL Week 12.
The site gives the Jaguars a 55.3% shot at winning the NFL Week 12 game, with the remaining percentage accounting for a tie.
Cardinals predicted record: 5-6
Cardinals NFL Week 13 prediction: Sunday, Nov. 30 at Tampa Bay Buccaneers, Fox, 11 a.m.
Cardinals have a 42.4% chance to beat the Buccaneers in NFL Week 13.
The site gives the Buccaneers a 57.2% shot at winning the NFL Week 13 game, with the remaining percentage accounting for a tie.
Cardinals predicted record: 5-7
Cardinals NFL Week 14 prediction: Sunday, Dec. 7 vs. Los Angeles Rams, Fox, 2:25 p.m.
Cardinals have a 46.6% chance to beat the Rams in NFL Week 14.
The site gives the Rams a 53.1% shot at winning the NFL Week 14 game, with the remaining percentage accounting for a tie.
Cardinals predicted record: 5-8
Cardinals NFL Week 15 prediction: Sunday, Dec. 14 at Houston Texans, Fox, 11 a.m.
Cardinals have a 42.3% chance to beat the Texans in NFL Week 15.
The site gives the Texans a 57.4% shot at winning the NFL Week 15 game, with the remaining percentage accounting for a tie.
Cardinals predicted record: 5-9
Cardinals NFL Week 16 prediction: Sunday, Dec. 21 vs. Atlanta Falcons, Fox, 2:05 p.m.
Cardinals have a 55.9% chance to beat the Falcons in NFL Week 16.
The site gives the Falcons a 43.8% shot at winning the NFL Week 16 game, with the remaining percentage accounting for a tie.
Cardinals predicted record: 6-9
Cardinals NFL Week 17 prediction: Saturday or Sunday, Dec. 27-28 at Cincinnati Bengals, TBD
Cardinals have a 38.9% chance to beat the Bengals in NFL Week 17.
The site gives the Bengals a 60.8% shot at winning the NFL Week 17 game, with the remaining percentage accounting for a tie.
Cardinals predicted record: 6-10
Cardinals NFL Week 18 prediction: Saturday or Sunday, Jan. 3-4 at Los Angeles Rams, TBD
Cardinals have a 38.9% chance to beat the Rams in NFL Week 18.
The site gives the Rams a 60.8% shot at winning the NFL Week 18 game, with the remaining percentage accounting for a tie.
Cardinals predicted record: 6-11
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