The Week 4 college football schedule has a bit of everything for any bettor looking to make Week 4 college football picks. There are ranked matchups such as No. 11 Oklahoma vs. No. 22 Auburn (+7) and No. 9 Illinois vs. No. 19 Indiana (-6). You can also find in-state rivalry matchups like No. 4 Miami vs. Florida (+7.5) and No. 6 Oregon vs. Oregon State (+35.5). You can also find a slim college football spread with Arizona State vs. Baylor (-2.5).<\/p>\n
Having options is the perfect setup to making college football picks, no matter the type of matchup you prefer to wager on. Which of the Week 4 college football lines are the ones you should target? Before locking in any Week 4 college football picks, be sure to see the latest Week 4 college football predictions from SportsLine’s proven model<\/a>.<\/p>\n The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college football spread picks, and is a profitable 32-20 combined on money-line and over\/under\u00a0college football picks<\/a>\u00a0since the beginning of 2024. Anybody following its\u00a0college football betting<\/a>\u00a0picks at\u00a0sportsbooks<\/a>\u00a0and on\u00a0betting sites<\/a>\u00a0could have seen strong returns.<\/p>\n Now, it has turned its attention to the latest college football odds<\/a>\u00a0and Week 4\u00a0college football betting<\/a> lines on the spread, money line, and over\/under.\u00a0Head here to see every pick<\/a>.\u00a0<\/p>\n New users can also target the\u00a0DraftKings promo code<\/a>, which offers new users\u00a0$200 in bonus bets instantly plus over $200 off NFL Sunday Ticket<\/a>:<\/p>\n Top college football predictions for Week 4<\/p>\n One of the college football picks the model is high on during Week 4: Bill Belichick and North Carolina<\/a> (+7, 47.5) cover versus UCF<\/a> in a 3:30 p.m. ET Saturday kickoff. UNC has gotten better each week since dropping its opener as it then beat Charlotte by 17 points in Week 2 before blowing out Richmond by 35 points last Saturday. The Heels covered in both games, while UCF’s last two weeks have consisted of a bye and a non-FBS opponent. The Knights haven’t fully embraced the role of a favorite as they are just 3-7 ATS when favored since the start of 2024. UNC is projected to cover well over 60% of the time, per the model.\u00a0See which other picks the model likes here<\/a>.<\/p>\n Another prediction: USC<\/a> (-18.5, 56.5) covers at home versus Michigan State<\/a> at 11 p.m. ET on Saturday in more than 60% of simulations. The USC offense has been everything Lincoln Riley has imagined as the Trojans top FBS in points scored, yards gained and yards per play. Quarterback Jayden Maiava has eight total touchdowns with no picks, and the USC defense is also holding opponents to just 2.9 yards per rush. As for the Spartans, they are 0-3 versus the spread this season and have been among the worst teams in covering dating back to last year. Michigan State is 3-11-1 ATS since the start of 2024, which is the worst mark in the Big Ten. The model calls for the Trojans to win by more than three touchdowns, and it says the Over hits in more than 50% of simulations.\u00a0See the rest of the model’s picks here<\/a>.<\/p>\n How to make college football picks for Week 4<\/p>\n The model has also made the call on who wins and covers in every FBS matchup in Week 4, and it’s calling for multiple upsets, including an SEC team going down.\u00a0You can only get every pick for every game at SportsLine<\/a>, and for a limited time you can use promo code CHAMPIONSHIP to get your first month at SportsLine for $1.<\/p>\n So what college football picks can you make with confidence, and which underdogs win outright? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $2,000 in profit since its inception<\/a>, and find out.<\/p>\n Week 4 college football odds for notable games<\/p>\n