But there’s one that Pro Football Network sees as the Chiefs’ toughest game, and it sees their rivalry with the Buffalo Bills reignite with Kansas City again having to travel to Highmark Stadium in Orchard Park, the scene of their playoff triumph last season.<\/p>\n
“The Bills don\u2019t fear the Chiefs, but they haven\u2019t been able to beat them under the brightest of lights in the postseason,” Pro Football Network writes<\/a>. “However, Buffalo is actually 4-3 in their past seven games against Kansas City, making a trip to Upstate New York the most difficult game for the Chiefs entering the 2025 regular season.”<\/p>\n Kansas City Chiefs guard Trey Smith (65) blocks Buffalo Bills defensive end Greg Rousseau (50) in pursuit of quarterback Patrick Mahomes (15). Mark Konezny-Imagn Images<\/p>\n It is an odd dynamic that the Chiefs and Bills have.<\/p>\n Advertisement<\/p>\n Kansas City has beaten Buffalo the last four times in the playoffs, but in what is a wacky stat, the Bills have beaten the Chiefs the last four times they’ve played in the regular season.<\/p>\n Go figure.<\/p>\n So the Chiefs will get a chance to slay the Bills, and do so for the first time in the regular season since 2020, with Buffalo able to get the better of Mahomes and Reid time and time again.<\/p>\n Will it be the “toughest” game on the schedule? There’s every chance it just might be.<\/p>\n Related: Chiefs Urged To Sign 3-Time Pro Bowler As Final Puzzle Piece<\/a><\/p>\n![\"Kansas](\"https:\/\/www.rawchili.com\/nfl\/wp-content\/uploads\/2025\/05\/9903fea41f3b547adc9a0811dd6095ab.jpeg\"\/)
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