Defensive stars Nick Bosa and Fred Warner remain on injured reserve for San Francisco, as are defensive end Mykel Williams, a first-round pick in 2025, and season-opening starter at left guard Ben Bartch.<\/p>\n
On top of those injuries, the 49ers listed five players as questionable for the showdown against the Seahawks: left tackle Trent Williams, tight end George Kittle, wide receiver Ricky Pearsall, defensive end Keion White and cornerback Upton Stout. All five are starters or play a significant role for the team.<\/p>\n
ESPN 49ers beat reporter Nick Wagoner<\/a> shared Williams and White are the two questionable 49ers he believes are most unlikely to suit up against Seattle when he joined Seattle Sports\u2019 Brock and Salk to preview the matchup on Friday.<\/p>\n<\/p>\n White, who has 19 pressures and 1.5 sacks in eight games this season, is dealing with a groin injury. Wagoner noted the third-year pass rusher did participate in practice a bit for the first time this week on Thursday, but since San Francisco didn\u2019t do any work at full speed this week, it\u2019s tough to tell which way he is trending.<\/p>\n As for Williams, Wagoner would be surprised if the 12-time Pro Bowler and four-time All-Pro is able to overcome his hamstring injury and play. The 37-year-old Williams was injured during San Francisco\u2019s first offensive snap in its Week 17 win over the Chicago Bears.<\/p>\n \u201cObviously, that\u2019s the big injury there that we\u2019re all kind of keeping an eye on,\u201d Wagoner said of the 15-year NFL veteran. \u201cThis is the first soft-tissue injury of his career, a long career, and so he doesn\u2019t really know exactly how it\u2019s going to react. He doesn\u2019t know exactly what the recovery process is.\u201d<\/p>\n The Williams injury is certainly a big one for the 49ers. However, Wagoner noted they were still able to put up 42 points on Chicago last week while Williams missed essentially the entire game.<\/p>\n Wagoner said Williams has made some progress this week and looked better walking around the team facility this week than he did after the hamstring cropped up on Sunday. But even if Williams were able to tough it out and play, he doesn\u2019t believe it\u2019s a risk the Niners would be willing to take.<\/p>\n \u201cThe other complicating factor is, yes, this is a huge, huge game for both teams here, but it is not an end-your-season game if you lose. So there is risk there if you play Trent Williams,\u201d Wagoner said. \u201cWhat if he has a set back and now you\u2019re losing him for the games that could eliminate you and end your season? That\u2019s a tough needle to thread. My guess is you probably won\u2019t see him. I wouldn\u2019t completely rule it out. I\u2019d never say never, but I think he\u2019s the one that\u2019s the most questionable out of that group.\u201d<\/p>\n Hear the full conversation at this link<\/a> or in the audio player in this story. Listen to Brock and Salk weekdays from 6-10 a.m. or find the podcast on the Seattle Sports app.\u00a0<\/p>\n More on the Seattle Seahawks<\/p>\n \u2022 Stacy Rost: 2 numbers that matter for Seahawks vs 49ers<\/a>
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\u2022\u00a0The Reset: The reasons why Seattle Seahawks will beat the 49ers<\/a>
\u2022\u00a0Seahawks-49ers Injury Report: Shaheed to play; Cross ruled out<\/a><\/p>\n
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