The Detroit Red Wings (5-1-0) visit the Buffalo Sabres (2-4-0) for a Wednesday battle at the KeyBank Center in Buffalo, New York. The start time will be 7:30 p.m. ET (TNT). Let’s analyze BetMGM Sportsbook’s NHL odds around the Red Wings vs. Sabres odds and make our expert NHL picks and predictions.

2024-25 season series: Detroit won 3-1

The Red Wings tote a 5-game win streak into this contest. In its most recent game Sunday, +121 Detroit topped the Edmonton Oilers 4-2 (push 6.0). That game was at home; the Wings’ trip to Buffalo marks the club’s second road game of the season.

The Sabres last played Monday when they were a +123 underdog at the Montreal Canadiens. Buffalo lost 4-2 (push 6.0), which snapped a 2-game win streak.

Watch the NHL on Fubo!

Red Wings at Sabres odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 6:35 a.m. ET.

Moneyline (ML): Red Wings -110 (bet $110 to win $100) | Sabres -110 (bet $110 to win $100)Puck line (PL)/Against the spread (ATS): Red Wings +1.5 (-220) | Sabres -1.5 (+275)Over/Under (O/U): 6 (O: -115 | U: -105)Red Wings at Sabres projected goalies

John Gibson (2-1-0, 2.98 GAA, .873 SV%) vs. Alex Lyon (2-4-1, 2.54 GAA, .924 SV%)

Gibson made 16 saves while facing 18 shots in Sunday’s 4-2 win over the Oilers. He had stopped 31-of-32 in Detroit’s previous game; a start Tuesday would mark his third in a row.

Lyon parried away 27-of-30 shots in Monday’s 4-2 loss to Montreal. He owns a .928 SV% across 4 home games this season; for Lyon’s career he owns a fine .912 SV% on home ice.

Red Wings at Sabres picks and predictionsPrediction

Sabres 3, Red Wings 2

Detroit, which went 17-19-5 on the road last season, is playing awayn from home for just the second time this season. The Red Wings figure to have been fortunate thus far with shooting and save percentages, and with their 5-on-5 analytics are a fade candidate for the intermediate term.

Buffalo has solid Corsi numbers over recent games and overall this season has been hurt by a low conversion rate on its 5-on-5 high-danger looks. The Sabres have been terrific on the penalty kill (95.8%), and Lyon has a history of posting good numbers at home and in the month of October.

TAKE BUFFALO (-110).

No interest; PASS.

The Under is 3-0-1 across Detroit’s last 4 games and is 3-1 in Buffalo’s 4 home games thus far.

The Red Wings had shaky offensive output on 2 days’ rest last season, and both penalty kill groups have been sharp so far.

It’s a sliver of a lean here, but it’s a lean, on the UNDER 6 (-105).

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

Follow SportsbookWire on Twitter/X and like us on Facebook.