Carter Verhaeghe, Sam Bennett and Anton Lundell scored for the Panthers (18-13-2), who have won six of their past seven. Brad Marchand had two assists, and Daniil Tarasov made 27 saves.
Joel Armia and Kevin Fiala scored for Los Angeles (14-10-9) which has lost four straight (0-2-2). Anton Forsberg made 25 saves for the Kings.
Armia gave Los Angeles a 1-0 lead at 13:39 of the first period on the power play, scoring just the second goal on the Florida penalty kill this month when he deflected a shot from Brandt Clarke that dropped to the ice and went between the skates of Tarasov.
Florida has successfully killed off 29 of 31 penalties thus far in December, including three of four on Wednesday.
Lundell’s power-play goal tied it 1-1 at 2:14 of the second period when he redirected a point shot from Aaron Ekblad.
Verhaeghe gave Florida a 2-1 lead at 7:04, scoring off a shot toward a crowd in front of the net, with the puck hitting a Los Angeles defender and sneaking past Forsberg. It was his ninth goal in the past 11 games.
Bennett scored 10 seconds into the third period to make it 3-1. Marchand intercepted a clearing attempt deep in the zone before sending a quick, sharp-angled shot to the net that hit the stick of Bennett and went past Forsberg.
Los Angeles cut it to 3-2 at 4:48. Florida defenseman Gustav Forsling went to clear the puck from near his own goal line, but the puck hit Fiala in the shin pad and went about 20 feet at a sharp angle toward the Florida net and in.