Lightning vs Blues NHL Prediction, Odds, Picks, Best Bets for Dec. 22

On Monday in the NHL, the Tampa Bay Lightning are playing the St. Louis Blues.

Before you make your wager on FanDuel Sportsbook, we’ve got you covered, in terms of the most important info regarding today’s NHL betting odds.

Lightning vs Blues Game InfoTampa Bay Lightning (19-13-3) vs. St. Louis Blues (14-15-8)Date: Monday, December 22, 2025Time: 7 p.m. ETVenue: Benchmark International Arena — Tampa, FloridaCoverage: ESPN+Lightning vs Blues Odds

All NHL odds, betting lines and prop bets are available on FanDuel Sportsbook.

Lightning vs Blues Prediction & Pick

All NHL win probability predictions and picks are according to numberFire.

Prediction: Lightning win (75.9%)Lightning vs Blues Puck LineThe Lightning are favored by 1.5 goals against the Blues. The Lightning are +104 to cover the spread, while the Blues are -128.Lightning vs Blues Over/UnderThe Lightning-Blues game on Dec. 22 has been given an over/under of 5.5 goals. The over is -122 and the under is +100.Lightning vs Blues MoneylineThe Lightning vs Blues moneyline has Tampa Bay as a -250 favorite, while St. Louis is a +202 underdog on the road.Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!